A Case of Muscle Invasive Bladder Cancer Treated With Systemic Chemotherapy During Pregnancy

Abstract

Bladder cancer during pregnancy is rare and there are no previous reports of the use combination chemotherapy being administered for muscle invasive bladder cancer (MIBC) during pregnancy. We report a case of muscle invasive bladder cancer diagnosed during pregnancy and treated during the second and third trimester with 2 cycles of systemic chemotherapy using Carboplatin and Adriamycin. We considered this novel combination regime to have activity against bladder cancer, but be safer in pregnancy than the standard regimes. After receiving chemotherapy, the neonate was delivered at 32 weeks by caesarean section and suffered no ill effects from the chemotherapy. The infant continues to develop normally. The patient went on to receive radical bladder radiotherapy.



doi:10.4021/jcgo7e