J Clin Gynecol Obstet

Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc

Journal website http://www.jcgo.org

Original Article

Volume 3, Number 1, February 2014, pages 14-21

Predictors of Obstetrical Complications: A Prospective Cohort Study

**Table 1.** Clinical Criteria of the Study
Condition	Severity criteria
BP: blood pressure; IUGR: intrauterine growth restriction.
Preeclampsia	Systolic BP 140-160 mmHg; Diastolic BP 90 - 100 mmHg; Proteinuria < 0.3 g/24 hours.	Systolic BP 140 - 160 mmHg; Diastolic BP 90 - 110 mmHg; Proteinuria 0.3 - 0.5 g/24 h.	Systolic BP > 160 mmHg; Diastolic BP > 110 mmHg; Proteinuria > 0.5 g/24 h.
Abruptio placentae	–	–	Abdominal pain or vaginal bleeding; Sonographic signs of placental abruption or fetal distress.
IUGR	Hypotrophic IUGR, fetal hypotrophy	Asymmetrical IUGR, small-for-gestational-age fetus.	Symmetrical IUGR, Fetal weight < 10 percentile.
Preterm labor	Labor at 35 - 37 weeks of gestation; Weight at birth < 2,500 g.	Labor at 32 - 34 weeks of gestation; Weight at birth < 2,000 g.	Labor at 28 - 31 weeks of gestation; Weight at birth < 1,500 g.
Intrauterine hypoxia	Conditions that require supplementary support in the delivery room.	Conditions that require additional care at the maternity department.	Conditions that require additional care at the neonatal unit; Conditions that caused death in perinatal, neonatal periods.

Table 1. Clinical Criteria of the Study

Condition

Severity criteria

Mild

Moderate

Severe

BP: blood pressure; IUGR: intrauterine growth restriction.

Preeclampsia

Systolic BP 140-160 mmHg;
Diastolic BP 90 - 100 mmHg;
Proteinuria < 0.3 g/24 hours.

Systolic BP 140 - 160 mmHg;
Diastolic BP 90 - 110 mmHg;
Proteinuria 0.3 - 0.5 g/24 h.

Systolic BP > 160 mmHg;
Diastolic BP > 110 mmHg;
Proteinuria > 0.5 g/24 h.

Abruptio placentae

–

Abdominal pain or vaginal bleeding;
Sonographic signs of placental abruption or fetal distress.

IUGR

Hypotrophic IUGR, fetal hypotrophy

Asymmetrical IUGR, small-for-gestational-age fetus.

Symmetrical IUGR,
Fetal weight < 10 percentile.

Preterm labor

Labor at 35 - 37 weeks of gestation;
Weight at birth < 2,500 g.

Labor at 32 - 34 weeks of gestation;
Weight at birth < 2,000 g.

Labor at 28 - 31 weeks of gestation;
Weight at birth < 1,500 g.

Intrauterine hypoxia

Conditions that require supplementary support in the delivery room.

Conditions that require additional care at the maternity department.

Conditions that require additional care at the neonatal unit; Conditions that caused death in perinatal, neonatal periods.

**Table 2.** Inclusion/Exclusion Into the Study
Inclusion	Exclusion
Screened, N = 2,497	Inclusion criteria not met (n = 123). Refused to participate (n = 18).
Recruited, N = 2,356	Multiple pregnancies (n = 9). Spontaneous abortion before 28 weeks (n = 61). Congenital fetal anomalies (n = 7). Primary or recurring infection in the woman (n = 9). Lost to follow-up (n = 58).
Completed study, N = 2,212	Chorioamnionitis (n = 1). Hemolytic disease of newborn (n = 1). Congenital anomalies in a neonate (n = 5). Congenital infections in a neonate (n = 4). Missing data (n = 24).
Included into analysis, N = 2,177	Main group (n = 1,684). Control group (n = 493).

Table 2. Inclusion/Exclusion Into the Study

Inclusion

Exclusion

Screened, N = 2,497

Inclusion criteria not met (n = 123).
Refused to participate (n = 18).

Recruited, N = 2,356

Multiple pregnancies (n = 9).
Spontaneous abortion before 28 weeks (n = 61).
Congenital fetal anomalies (n = 7).
Primary or recurring infection in the woman (n = 9).
Lost to follow-up (n = 58).

Completed study, N = 2,212

Chorioamnionitis (n = 1).
Hemolytic disease of newborn (n = 1).
Congenital anomalies in a neonate (n = 5).
Congenital infections in a neonate (n = 4).
Missing data (n = 24).

Included into analysis, N = 2,177

Main group (n = 1,684).
Control group (n = 493).

**Table 3.** Obstetrical and Perinatal Complications in the Study Cohort
Complications	Mild N = 1,165	Moderate N = 340	Severe N = 179	Total
abs: absolute value.
Abruptio placentae	−	−	−	−	20	100.0	20
Preeclampsia	407	60.93	156	23.35	105	15.72	668
Preterm labor	206	51.24	123	30.60	73	18.16	402
IUGR	267	62.97	75	17.69	82	19.34	424
Intrauterine hypoxia	412	60.59	161	23.68	107	15.74	680

Table 3. Obstetrical and Perinatal Complications in the Study Cohort

Complications

Mild
N = 1,165

Moderate
N = 340

Severe
N = 179

Total

abs

abs: absolute value.

Abruptio placentae

−

100.0

Preeclampsia

407

60.93

156

23.35

105

15.72

668

Preterm labor

206

51.24

123

30.60

18.16

402

IUGR

267

62.97

17.69

19.34

424

Intrauterine hypoxia

412

60.59

161

23.68

107

15.74

680

**Table 4.** Major Quantitative Parameters in the Study Cohort
Descriptive statistics	Maternal age, years	Body mass index, kg/m²	Term at birth, weeks	Body weight of neonate, g
No complications N = 493	Mean	24.82	23.98	38.51	3,492
SD	5.01	3.28	0.77	282.6
Median	24	23.7	38	3,450
Minimum	16	16,8	37	2,920
Maximum	41	34.2	41	4,650
Mild complications N = 1,165	Mean	25.6	23.47	38.27	3,239
SD	5.47	3.63	1.33	657.5
Median	25	23.1	39	3,370
Minimum	16	16.5	35	2,000
Maximum	42	34.4	42	4,460
Moderate complications N = 340	Mean	27.47	25.87	37.13	3,138
SD	5.94	4.53	1.82	556.9
Median	28	25.9	37	3,085
Minimum	17	16.8	32	1,515
Maximum	42	34.2	41	4,500
Severe complications N = 179	Mean	26.85	24.74	36.23	2,752
SD	6.22	4.39	3	744.6
Median	26	23.7	37	2,910
Minimum	16	17.6	28	1,090
Maximum	39	33.3	40	4,340

Table 4. Major Quantitative Parameters in the Study Cohort

Descriptive statistics

Maternal age, years

Body mass index, kg/m²

Term at birth, weeks

Body weight of neonate, g

No complications
N = 493

Mean

24.82

23.98

38.51

3,492

5.01

3.28

0.77

282.6

Median

23.7

3,450

Minimum

16,8

2,920

Maximum

34.2

4,650

Mild complications
N = 1,165

Mean

25.6

23.47

38.27

3,239

5.47

3.63

1.33

657.5

Median

23.1

3,370

Minimum

16.5

2,000

Maximum

34.4

4,460

Moderate complications
N = 340

Mean

27.47

25.87

37.13

3,138

5.94

4.53

1.82

556.9

Median

25.9

3,085

Minimum

16.8

1,515

Maximum

34.2

4,500

Severe complications
N = 179

Mean

26.85

24.74

36.23

2,752

6.22

4.39

744.6

Median

23.7

2,910

Minimum

17.6

1,090

Maximum

33.3

4,340