J Clin Gynecol Obstet

Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc

Journal website http://www.jcgo.org

Original Article

Volume 4, Number 4, December 2015, pages 302-306

Comparison of Misoprostol and Dinoprostone Gel for Induction in Prelabor Rupture of Membranes at Term

**Table 1.** Demographic and Clinical Characteristics in Group I
Characteristic	Misoprostol (n = 25)	Dinoprostone (n = 25)	P value
Age (years)	22.2	21.4	0.899
Gestational age (weeks)	39	40	0.500
Bishop’s score < 6	13	18	0.145

Table 1. Demographic and Clinical Characteristics in Group I

Characteristic

Misoprostol (n = 25)

Dinoprostone (n = 25)

P value

Age (years)

22.2

21.4

0.899

Gestational age (weeks)

0.500

Bishop’s score < 6

0.145

**Table 2.** Demographic and Clinical Characteristics in Group II
Characteristic	Misoprostol (n = 25)	Dinoprostone (n = 25)	P value
Age	25.6	26.1	0.566
Gestational age (weeks)	39	39	1
Bishop’s score < 6	17	21	0.162

Table 2. Demographic and Clinical Characteristics in Group II

Characteristic

Misoprostol (n = 25)

Dinoprostone (n = 25)

P value

Age

25.6

26.1

0.566

Gestational age (weeks)

Bishop’s score < 6

0.162

**Table 3.** Demographic and Clinical Characteristics
Characteristic	Misoprostol (n = 50)	Dinoprostone (n = 50)	P value
Age (years)	23.02	23.09	0.867
Gestational age	38.40	38.26	0.899
Bishop’s score < 6	30	39	0.05

Table 3. Demographic and Clinical Characteristics

Characteristic

Misoprostol (n = 50)

Dinoprostone (n = 50)

P value

Age (years)

23.02

23.09

0.867

Gestational age

38.40

38.26

0.899

Bishop’s score < 6

0.05

**Table 4.** Total Number of Doses Required for Induction in Group I
Number	Misoprostol group (n = 25)	Dinoprostone group (n = 25)	P value
1	19	76	23	92	0.122
2	4	16	2	8	0.384
3	2	8	0	0	0.148
Oxytocin during labor	5	20	6	24	0.732

Table 4. Total Number of Doses Required for Induction in Group I

Number

Misoprostol group (n = 25)

Dinoprostone group (n = 25)

P value

Number

Percentage

Number

Percentage

0.122

0.384

0.148

Oxytocin during labor

0.732

**Table 5.** Total Number of Doses Required for Induction in Group II
Number	Misoprostol group (n = 25)	Dinoprostone group (n = 25)	P value
1	22	88	21	84	0.683
2	3	12	4	16	0.683
3	0	0	0	0
Oxytocin during labor	3	12	2	8	0.637

Table 5. Total Number of Doses Required for Induction in Group II

Number

Misoprostol group (n = 25)

Dinoprostone group (n = 25)

P value

Number

Percentage

Number

Percentage

0.683

Oxytocin during labor

0.637

**Table 6.** Induction to Delivery Interval in Group I
	Total number of patients	Induction delivery interval (in h)	P value
Misoprostol group	25	7.748 ± 5.18	0.590
Dinoprostone group	25	7.07 ± 3.46

Table 6. Induction to Delivery Interval in Group I

Total number of patients

Induction delivery interval (in h)

P value

Misoprostol group

7.748 ± 5.18

0.590

Dinoprostone group

7.07 ± 3.46

**Table 7.** Induction to Delivery Interval in Group II
	Total number of patients	Induction delivery interval (in h)	P value
Misoprostol group	25	5.55 ± 3.9	0.301
Dinoprostone group	25	6.71 ± 3.8

Table 7. Induction to Delivery Interval in Group II

Total number of patients

Induction delivery interval (in h)

P value

Misoprostol group

5.55 ± 3.9

0.301

Dinoprostone group

6.71 ± 3.8

**Table 8.** Induction to Delivery Interval in 100 Induced Patients
	Total number of patients	Induction delivery interval (in h)	P value
Misoprostol group	50	6.652 ± 4.6	0.777
Dinoprostone group	50	6.89 ± 3.6

Table 8. Induction to Delivery Interval in 100 Induced Patients

Total number of patients

Induction delivery interval (in h)

P value

Misoprostol group

6.652 ± 4.6

0.777

Dinoprostone group

6.89 ± 3.6

**Table 9.** Mode of Delivery in Induced Patients in Group I
Mode of delivery	Misoprostol group (n = 25)	Dinoprostone group (n = 25)	P value
Cesarean section	1	1	1.00
Vaginal delivery	24	24	1.00

Table 9. Mode of Delivery in Induced Patients in Group I

Mode of delivery

Misoprostol group (n = 25)

Dinoprostone group (n = 25)

P value

Cesarean section

1.00

Vaginal delivery

1.00

**Table 10.** Mode of Delivery in Induced Patients in Group II
Mode of delivery	Misoprostol group (n = 25)	Dinoprostone group (n = 25)
Cesarean section	0	0
Vaginal delivery	25	25

Table 10. Mode of Delivery in Induced Patients in Group II

Mode of delivery

Misoprostol group (n = 25)

Dinoprostone group (n = 25)

Cesarean section

Vaginal delivery

**Table 11.** Maternal Adverse Effects
Adverse effects	Misoprostol group	Dinoprostone group	P value
Nausea and vomiting	1	2	0.557
Diarrhoea	4	0	0.041
Hyperthermia	1	2	0.557
Uterine tachysystole	2	1	0.557
Chorioamnionitis	1	1	1
Postpartum fever	1	1	1
Foul smelling lochia	1	1	1
Wound infection	1	1	1

Table 11. Maternal Adverse Effects

Adverse effects

Misoprostol group

Dinoprostone group

P value

Nausea and vomiting

0.557

Diarrhoea

0.041

Hyperthermia

0.557

Uterine tachysystole

0.557

Chorioamnionitis

Postpartum fever

Foul smelling lochia

Wound infection

**Table 12.** Neonatal Outcome in Group I
Variables	Misoprostol	Dinoprostone
Birth weight (kg)	2.71	2.74
Apgar score < 6 at 1 min	2	2
Apgar score < 8 at 1 min	2	2

Table 12. Neonatal Outcome in Group I

Variables

Misoprostol

Dinoprostone

Birth weight (kg)

2.71

2.74

Apgar score < 6 at 1 min

Apgar score < 8 at 1 min

**Table 13.** Neonatal Outcome in Group II
Variables	Misoprostol	Dinoprostone
Birth weight (kg)	2.73	2.76
Apgar score < 6 at 1 min	0	1
Apgar score < 8 at 1 min	0	1

Table 13. Neonatal Outcome in Group II

Variables

Misoprostol

Dinoprostone

Birth weight (kg)

2.73

2.76

Apgar score < 6 at 1 min

Apgar score < 8 at 1 min

**Table 14.** Neonatal Morbidities
NICU admission	Misoprostol group	Dinoprostone group	P value
Respiratory distress	1	0	0.31
Early onset sepsis	1	1	1
Birth asphyxia	1	3	0.307

Table 14. Neonatal Morbidities

NICU admission

Misoprostol group

Dinoprostone group

P value

Respiratory distress

0.31

Early onset sepsis

Birth asphyxia

0.307