| Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc |
| Journal website http://www.jcgo.org |
Original Article
Volume 6, Number 1, March 2017, pages 12-16
Role of 17-Hydroxyprogesterone Caproate as an Adjuvant Therapy in Women With Cervical Cerclage for Prevention of Preterm Delivery: A Retrospective Matched Controlled Study
Tables
| Characteristics | Group 1: cerclage plus 17-OHP, n = 64 (%) | Group 2: cerclage only, n = 58 (%) |
|---|---|---|
| Age (mean ± SD) | 31 ± 4.1 | 30 ± 5 |
| Gravida, mean (range) | 4.13 (1 - 11) | 3.95 (1 - 10) |
| Para, mean (range) | 1.3 (0 - 7) | 1.45 (0 - 5) |
| Previous second trimester miscarriage | ||
| No | 32 (50%) | 27 (47%) |
| Yes | 32 (50%) | 31 (53%) |
| Previous preterm | ||
| No | 31 (48%) | 32 (55%) |
| Yes | 33 (52%) | 26 (45%) |
| Previous still birth | ||
| No | 60 (94%) | 57 (98%) |
| Yes | 4 (6%) | 1 (2%) |
| Previous neonatal death | ||
| No | 52 (81%) | 48 (83%) |
| Yes | 12 (19%) | 10 (17%) |
| Previous cerclage | ||
| No | 33 (52%) | 28 (48%) |
| Yes | 31 (48%) | 30 (52%) |
| Cervical length before cerclage | ||
| < 2.5 cm | 16 (25%) | 16 (28%) |
| ≥ 2.5 cm | 48 (75%) | 42 (72%) |
| Vaginal infection | ||
| No | 44 (69%) | 37 (64%) |
| Yes | 20 (31%) | 21 (36%) |
| Outcome | Group 1: cerclage plus 17-OHP, n = 64 (%) | Group 2: cerclage only, n = 58 (%) | P value |
|---|---|---|---|
| Emergency cerclage removal | 0.8 | ||
| No | 46 (53%) | 41 (47%) | |
| Threatened preterm | 14 (54%) | 12 (46%) | |
| Premature rupture of membrane | 4 (44%) | 5 (56%) | |
| Miscarriage | 0.2 | ||
| No | 60 (51%) | 57 (49%) | |
| Yes | 4 (80%) | 1 (20%) | |
| Spontaneous vaginal delivery | 0.1 | ||
| No | 19 (63%) | 11 (37%) | |
| Yes | 45 (49%) | 47 (51%) | |
| LSCS | 0.3 | ||
| No | 49 (51%) | 48 (49%) | |
| Yes | 15 (60%) | 10 (40%) | |
| Fetal outcome | 0.4 | ||
| Alive | 60 (52%) | 56 (48%) | |
| Still birth and miscarriage | 4 (67%) | 2 (33%) | |
| Fetal weight | 0.4 | ||
| < 2.5 kg | 17 (47%) | 19 (53%) | |
| At 2.5 kg | 5 (7%) | 2 (29%) | |
| > 2.5 kg | 42 (53%) | 37 (47%) | |
| Apgar score at 1 min | 0.04 | ||
| 8 - 10 | 42 (46%) | 49 (54%) | |
| 5 - 7 | 10 (77%) | 3 (23%) | |
| < 5 | 12 (67%) | 6 (33%) | |
| Apgar score at 5 min | 0.7 | ||
| 8 - 10 | 57 (51%) | 54 (49%) | |
| 5 - 7 | 2 (67%) | 1 (33%) | |
| < 5 | 5 (63%) | 3 (37%) | |
| NICU admission | 0.2 | ||
| No | 47 (49%) | 48 (51%) | |
| Yes | 17 (63%) | 10 (37%) |
| Outcome (gestation in weeks) | Group 1: cerclage plus 17-OH P, n = 64 (%) | Group 2: cerclage only, n = 58 (%) | P value |
|---|---|---|---|
| Below 37 | |||
| No | 48 (53%) | 42 (47%) | 0.7 |
| Yes | 16 (50%) | 16 (50%) | |
| At 37 | |||
| No | 57 (54%) | 49 (46%) | 0.4 |
| Yes | 7 (44%) | 9 (56%) | |
| Above 37 | |||
| No | 23 (48%) | 25 (52%) | 0.4 |
| Yes | 41 (55%) | 33 (45%) |