Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc
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Case Report

Volume 6, Number 3-4, October 2017, pages 71-74

Distant Cutaneous Manifestations of a Primary Gynecologic Malignancy


Figure 1.
Figure 1. Hysterectomy specimen shows endometrial intraepithelial carcinoma (EIC) in an endometrial polyp.
Figure 2.
Figure 2. (a) Lesions on patient’s left breast. Distribution suggestive of herpes zoster. (b) Vulva and mons pubis, with a single lesion visible on posterior left vulva.
Figure 3.
Figure 3. Low power view of cutaneous punch biopsy (× 4) with immunostains.


Table 1. Summary of Patient’s Clinical Course
Months after presentationClinical events
EMB: endometrial biopsy; EIC: endometrial intraepithelial carcinoma; RA-TLH and RSO: robotic-assisted total laparoscopic hysterectomy and right salpingo-oophorectomy; SAR: subacute rehabilitation.
0Presented with vaginal bleeding, diagnosis of atypical hyperplasia on EMB
1Underwent RA-TLH and RSO, final pathology consistent with EIC
33Axillary lymph node recurrence on surveillance, systemic chemotherapy initiated (carboplatin and paclitaxel, followed by carboplatin and docetaxel), no evidence of disease after completion of chemotherapy
40Recurrence of disease, single-agent chemotherapy initiated (docetaxel)
47No response to treatment, chemotherapeutic agent changed (temsirolimus)
48Hospital admission for abdominal pain and fatigue, cutaneous lesions noted
49Hospital admission for bowel obstruction, exploratory laparotomy with loop colostomy, discharge to SAR