Association of Coronary Heart Disease Risk and Lipid Profile in Indian Women With Polycystic Ovarian Syndrome

Abstract

Background: Polycystic ovarian syndrome (PCOS) has been one of the major public health problems in India. Women with PCOS are often assumed, a priori, to be at increased risk for cardiovascular disease, given the high prevalence of the metabolic syndrome X among them. Lipoprotein (a) (Lp(a)) is an risk factor for development of atherosclerosis and along with dyslipidemia may add to cardiovascular risk. The aim of the study was to know the lipid profile variation in Indian women with PCOS.

Methods: This cross-sectional study was conducted in West Bengal state, India. The subjects enrolled for the study included 180 women with PCOS who were compared with 95 healthy women of the control group; all of them were age and weight matched. Samples were taken after overnight fasting, and then serum lipid levels were analyzed.

Results: The mean age of subjects was 28.71 4.12 years in the PCOS group and 30.14 3.29 years in the control group. The lipid profile parameters were comparable between patients and control subjects. There was a statistically significant difference in the Lp(a) levels between patients with PCOS and normal controls (P <= 0.0001). There were statistically significant increased levels of total cholesterol, very low-density lipoprotein and low-density lipoprotein cholesterol in PCOS group when compared with the control group (P < 0.05) and decreased level of high-density lipoprotein cholesterol.

Conclusion: The changed lipid profile levels may contribute to increased cardiovascular risk in PCOS patients.




J Clin Gynecol Obstet. 2016;5(1):23-26
doi: http://dx.doi.org/10.14740/jcgo375w

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