Increased Cys-C Levels in Hyperemesis Gravidarum

Cemil Bilir, Suleyman Akarsu, Nermin Akdemir, Feyzi Gokosmanoglu


Background: Serum cys-C is superior to serum creatinine as an index of GFR also it can be used to predict acute renal failure before the rise in serum creatinine. We aimed to investigate cys-C levels in pregnant patients with hyperemesis gravidaum because of volume loss of this common problem.

Method: Thirty-seven patients with hyperemesis gravidarum and 33 healthy controls were included the study. Serum cys-C and the other laboratory parameters compared with controls.

Results: The hyperemesis gravidaum group had higher levels of BUN; AST and ALT. Groups did not differ in age, weight, gestational week, hemoglobin, glucose or creatinine levels. Serum cys-C levels were also higher in the hyperemesis gravidaum group (1.007 vs 0.63, P 0.002). Stepwise multiple regression analysis with the dependent variable “Cys-C”. The model had two independent predictors and an R2 of 63.7 %. Predictors for cys-C were the number of vomiting episodes and the duration of hospitalization.

Conclusion: There is a significant correlation between both the number of vomiting episodes and the length of the hospital stay with cys-C levels in HG. Cys-C levels could serve as a beneficial marker (cys-C > 1 mg/L as a cut-off value) in the context of hospitalization criteria for HG in the outpatient clinic.



Hyperemesis gravidarum; Cystatin C; Hospitalization

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Journal of Clinical Gynecology & Obstetrics, quarterly, ISSN 1927-1271 (print), 1927-128X (online), published by Elmer Press Inc.                     
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