Methyldopa Hepatotoxicity: A Paradoxical High-Risk Pregnancy

Onameyore Utuama, Omofolarin Fasuyi, Gregory Strayhorn, Karla Lorraine Booker


Alpha methyldopa is one of the preferred medications for hypertension control in pregnant women because of its low teratogenic profile. However, when pregnant women on this medication develop an acute or chronic liver damage, methyldopa is not thought to be responsible. At 18 weeks gestation of a high-risk pregnancy, a patient with chronic hypertension controlled on methyldopa 500 mg three times daily, presented with jaundice, dark-colored urine and elevated liver function enzymes. Following worsening symptoms, inconclusive radiological and negative immunological laboratory investigations, she was hospitalized and a diagnosis of drug-induced hepatotoxicity was confirmed with a liver biopsy. Her symptoms resolved with withdrawal of the offending medication and prednisone taper, which led to diabetes mellitus in pregnancy. Paradoxically, following the diagnosis and discontinuation of methyldopa, the patients blood pressure remained controlled off antihypertensives.

J Clin Gynecol Obstet. 2015;4(3):271-274


Methyldopa; Pregnancy; Hepatotoxicity

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics






Journal of Clinical Gynecology & Obstetrics, quarterly, ISSN 1927-1271 (print), 1927-128X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal, the authors retain the copyright, the journal is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International
License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.