Distant Cutaneous Manifestations of a Primary Gynecologic Malignancy

Abstract

Uterine cancer is the most common gynecologic cancer in the United States. While most cases are diagnosed early and recurrence is rare with adequate treatment, late stage disease has a much worse prognosis, with 5-year survival rates of 25-45%. We report the presentation of recurrent uterine serous carcinoma with metastasis to the skin. An 80-year-old postmenopausal female with a history of endometrial intraepithelial carcinoma was diagnosed with recurrent metastatic disease 3 years after her initial presentation. During hospital admission, she was noted to have clusters of rubbery cutaneous nodules with an erythematous vesicular appearance on the left breast. Biopsy of the lesions showed metastatic serous adenocarcinoma consistent with gynecologic origin. Cutaneous metastasis is a rare finding in uterine cancer. This case highlights the importance of maintaining a wide differential diagnosis and high level of suspicion when evaluating skin lesions in the setting of uterine pathology.




J Clin Gynecol Obstet. 2017;6(3-4):71-74
doi: https://doi.org/10.14740/jcgo461w