Solitary Fibrous Tumor in the Vulva

Abstract

Solitary fibrous tumor (SFT) is a rare soft tissue tumor that is composed of fibroblastic tumor cells and collagenous stroma with NAB2-STAT6 gene rearrangement. Vulvar SFTs are extremely rare. We report a case of vulvar SFT and review the current literature. A 71-year-old woman presented with a slow-growing mass in her left labia majora. The patient also complained of urinary stream diversion. Physical examination revealed a tumor in the left labia majora, which manifested as a rubbery, immobile, and tender mass. Computed tomographic images showed an enhanced vulvar mass. Magnetic resonance imaging (MRI) demonstrated a well-defined tumor with heterogeneous intermediate signal intensity on T1-weighted images and heterogeneous high signal intensity on T2-weighted images. The tumor measured 68 45 57 mm on MRI and was located in the labia majora. Percutaneous needle biopsy revealed an SFT. Immunohistochemically, the tumor cells were positive for STAT6 and CD34. Local excision was performed with negative surgical margins. Preoperative needle biopsy was useful for diagnosis and planning a surgical strategy. Local resection of the vulvar SFT improved symptoms of urinary stream diversion. There was no tumor recurrence during the 4 years following the surgery.

J Clin Gynecol Obstet. 2023;12(1):19-23
doi: https://doi.org/10.14740/jcgo852