Conservative Management Outcome of Cervical Intraepithelial Neoplasia Grade 2: A Three-Year Follow-Up Study

Junaid Rafi, Haroona Khalil


Background: This study aimed to evaluate the safety and outcomes associated with the conservative management of cervical intraepithelial neoplasia grade 2 (CIN2) in women by assessing the rates of spontaneous regression of CIN2, persistence of CIN2, or progression to CIN3 and cancer.

Methods: We conducted a retrospective cohort study at DGH Hospital in the UK. We examined the medical records using the Infoflex system of 146 women with histologically confirmed CIN2 between April 1, 2019, and April 30, 2022. These patients underwent regular follow-ups every 6 months, including colposcopy, repeated cervical smears/punch biopsy, and human papillomavirus (HPV) testing to monitor the progression or regression of their cervical lesions. The analysis included assessing the rates of spontaneous regression of CIN2, progression to CIN3 and cancer, the duration of conservative management, and the number of patients who defaulted on follow-up.

Results: Among the 146 women with histologically confirmed CIN2, only 67 patients were eligible for conservative management. All cases underwent thorough evaluation by a multidisciplinary team (MDT); and out of these 67 cases, nine cases were upgraded after MDT review: six based on histological findings (punch biopsies) from CIN2 to CIN3, and three based on upgraded cytological assessments resulting in a total of 56 cases suitable for CIN2 management. Out of these 56 women; 39 women were in the age group between 25 and 30 years; 15 women between 30 and 35 age group; one patient was 36 years, and one patient was 40 years old. Regression rate was 71% (n = 40/56) with conservative management; two cases progressed to CIN3 (had large loop excision of the transformation zone (LLETZ) procedure) with no progression to cancer. At 6, 12, 18, and 24 months, the number of negative smears were 27/56 (48%), 5/56 (8.9%), 2/56 (3.5%), and 1/56 (1.7%), respectively.

Conclusions: Contrary to prior studies (upper age limit < 30 years), our findings support successful (71% regression rate) conservative management (CIN2) in women aged 25 - 40 years. Additionally, our observations highlight the quicker resolution of cytological abnormalities compared to histological regression.

J Clin Gynecol Obstet. 2024;13(1):8-11



Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics






Journal of Clinical Gynecology & Obstetrics, quarterly, ISSN 1927-1271 (print), 1927-128X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal, the authors retain the copyright, the journal is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International
License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.